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There are several different variations of glaucoma, but in this article we will mainly focus on Primary Open Angle Glaucoma. This means that there is no specific underlying cause for the glaucoma, like inflammation, trauma or a severe cataract. It also means that the drainage angle where fluid is drained from the inside of the eye into the bloodstream is not narrow or closed.
Closed or Narrow Angle Glaucoma, which we won't be discussing today, is treated differently from Open Angle Glaucoma
In the U.S., Primary Open Angle Glaucoma (POAG) is by far the most common type of glaucoma we treat.
Glaucoma is a disease where the optic nerve in the back of the eye deteriorates over time, and that deterioration has a relationship to the Intraocular Pressure (IOP). Most - but not all - people diagnosed with glaucoma have an elevated IOP. Some people have fairly normal IOP’s but show the characteristic deterioration in the optic nerve. Regardless of whether or not the pressure was high initially, our primary treatment is to lower the IOP. We usually are looking to try to get the IOP down by about 25% from the pre-treatment levels.
The two mainstays of initial treatment for POAG in the U.S. are medications and laser treatments. There are other places in the world where glaucoma is initially treated with surgery. However, while surgery can often lower the pressure to a greater degree than either medications or laser treatments, it comes with a higher rate of complications. Most U.S. eye doctors elect to go with the more conservative approach and utilize either medications, most often in the form of eye drops, or a laser treatment.
Drops
There are several different classes of medications used to treat glaucoma.
The most common class used are the Prostaglandin Analogues or PGA’s. Some of the PGA’s available in the U.S. are Xalatan (latanaprost), Travatan (travapost), Lumigan (bimatoprost) and Zioptan (tafluprost).
PGA’s are most doctors’ first line of treatment because they generally lower the IOP better than the other classes, they are reasonably well tolerated by most people, and they are dosed just once a day. Most of the other drugs available have to be used multiple times a day.
The other classes of drugs include beta-blockers that are used once or twice a day; carbonic anhydrase inhibitors (CAI’s ), which come in either a drop or pill form and are used either twice or three times a day; alpha agonists that are used either twice or three times a day; and miotics, which are used three or four times a day. All of these other medications are typically used as either second-line or adjunctive treatment when the PGA’s are not successful in keeping the pressure down as single agents.
There are also several combination drops available in the U.S. that combine two of the second-line agents (Cosopt, Combigan, and Symbrinza).
Laser
The second option for initial treatment is a laser procedure.
Two common laser treatments for Open Angle Glaucoma are Argon Laser Trabeculoplasty (ALT) or Selective Laser Trabeculoplasty (SLT). These treatments try to get an area inside the eye called the trabecular meshwork - where fluid is drained from the inside of the eye into the venous system - to drain more efficiently.
These treatments tend to lower the pressure to about the same degree as the PGA’s do with over 80% of patients achieving a significant decrease in their eye pressure that lasts at least a year. Both laser treatments can be repeated if the pressure begins to rise again in the future, but the SLT works slightly better as a repeat procedure compared to the ALT.
Article contributed by Dr. Brian Wnorowski, M.D.
This blog provides general information and discussion about eye health and related subjects. The words and other content provided in this blog, and in any linked materials, are not intended and should not be construed as medical advice. If the reader or any other person has a medical concern, he or she should consult with an appropriately licensed physician. The content of this blog cannot be reproduced or duplicated without the express written consent of Eye IQ.
Do you have family members with eye-related conditions?
The two main eye diseases in adults that have a genetic link are glaucoma and age-related macular degeneration (AMD).
Glaucoma is a deterioration of the optic nerve caused by pressure in the eye or poor blood flow to the optic nerve. It has no symptoms at its onset. In most cases if you wait to get glaucoma diagnosed until you begin to realize there is something wrong with your vision, upwards of 70% of your optic nerve will have already been destroyed. Once the nerve is destroyed there is no way of reversing that today and treatment is focused on trying to preserve whatever nerve tissue is left.
Your chances of getting glaucoma are four to 10 times higher if you have a close relative with glaucoma. Getting your eyes examined regularly is always important but even more so if there is a family history of glaucoma.
Macular degeneration is the leading cause of blindness in most of the developed world. It too can cause serious vision loss if you wait until you have significant symptoms before a diagnosis. There are now some preventative treatments for AMD--the earlier it is detected the better off you will be.
Having a close family member with AMD may increase your chances of having the disease as much as 50 percent, making timely diagnosis and treatment imperative.
Other eye diseases that run in families include strabismus (crossed eyes), myopia (nearsightedness), hyperopia (farsightedness), and astigmatism.
All of these family connections are important to know so that you and your eye doctor can together take the best possible care of your eyes. Before your next eye exam, ask your relatives if they have a history of eye disease. It might not make for the lightest of conversation at your next family gathering, but it could help save your vision.
Article contributed by Dr. Brian Wnorowski, M.D.
This blog provides general information and discussion about eye health and related subjects. The words and other content provided in this blog, and in any linked materials, are not intended and should not be construed as medical advice. If the reader or any other person has a medical concern, he or she should consult with an appropriately licensed physician. The content of this blog cannot be reproduced or duplicated without the express written consent of Eye IQ.
